Question 1

An angiotensin-converting enzyme (ACE. inhibitor for which both renal elimination and metabolism are important in the elimination of the drug and its active metabolites is:

Options :

A : enalapril

B : fosinopril

C : lisinopril

D : quinapril

E : ramipril

Answer: B

Question 2

Example of drug(s) used in treatment of tuberculosis include:

I- Isoniazid

II- Rifampin

III- Ethambutol

Options :

A : I only

B : III only

C :

I and II only

D : II and III only

E : All are correct

Answer: A

Question 3

Which of the following statements refers to flunisolide?

Options :

A : Penetrates placenta less readily than MMI

B : Causes fetal complications more frequently than PTU.

C : Is not as effective for acute attacks as beta-2 agonists.

D : Used only for maintenance/prophylaxis. Systemic steroids are used in case of acute exacerbations.

E : Cigarette smoking increases metabolism. Liver failure - decreases metabolism.

Answer: D

Question 4

Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by ? Assume the clearance value given in the previous question is entirely hepatic clearance.

Options :

A : 30 L/hr/70 Kg

B : 60 L/hr/70 Kg

C : 120 L/hr/70 Kg

D : 250 L/hr/70 Kg

Answer: A

Question 5

Agents considered as precursor of leukotriene include:

Options :

A : Tyrosine

B : Cyanide

C : Arachidonic acid

D : Prostaglandins

E : Histamine

Answer: C

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