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Exam Code: MCAT
Exam Questions: 815
Medical College Admission Test: Verbal Reasoning, Biological Sciences, Physical Sciences, Writing Sample
Updated: 19 Feb, 2026
Question 1

Our sense of smell is arguably the most powerful of our five senses, but it also the most elusive. It plays a vital
yet mysterious role in our lives. Olfaction is rooted in the same part of the brain that regulates such essential
functions as body metabolism, reaction to stress, and appetite. But smell relates to more than physiological
function: its sensations are intimately tied to memory, emotion, and sexual desire. Smell seems to lie
somewhere beyond the realm of conscious thought, where, intertwined with emotion and experience, it shapes
both our conscious and unconscious lives.
The peculiar intimacy of this sense may be related to certain anatomical features. Smell reaches the brain more
directly than do sensations of touch, sight, or sound. When we inhale a particular odor, air containing volatile
odiferous molecules is warmed and humidified as it flows over specialized bones in the nose called turbinates.
As odor molecules land on the olfactory nerves, these nerves fire a message to the brain. Thus olfactory
neurons render a direct path between the stimulus provided by the outside environment and the brain, allowing
us to rapidly perceive odors ranging from alluring fragrances to noisome fumes.
Certain scents, such as jasmine, are almost universally appealing, while others, like hydrogen sulfide (which
emits a stench reminiscent of rotten eggs), are usually considered repellent, but most odors evoke different
reactions from person to person, sometimes triggering strong emotional states or resurrecting seemingly
forgotten memories. Scientists surmise that the reason why we have highly personal associations with smells is
related to the proximity of the olfactory and emotional centers of our brain. Although the precise connection
between emotion and olfaction remains a mystery, it is clear that emotion, memory, and smell are all rooted in a
part of the brain called the limbic lobe.
Even though we are not always conscious of the presence of odors, and are often unable to either articulate or
remember their unique characteristics, our brains always register their existence. In fact, such a large amount
of human brain tissue is devoted to smell that scientists surmise the role of this sense must be profound.
Moreover, neurobiological research suggests that smell must have an important function because olfactory
neurons can regenerate themselves, unlike most other nerve cells. The importance of this sense is further
supported by the fact that animals experimentally denied the olfactory sense do not develop full and normal
brain function.
The significance of olfaction is much clearer in animals than in human beings. Animal behavior is strongly
influenced by pheromones, which are odors that induce psychological or behavioral changes and often provide
a means of communicating within a species. These chemical messages, often a complex blend of compounds,
are of vital importance to the insect world. Honeybees, for example, organize their societies through odor: the
queen bee exudes an odor that both inhibits worker bees from laying eggs and draws drones to her when she
is ready to mate. Mammals are also guided by their sense of smell. Through odors emitted by urine and scent
glands, many animals maintain their territories, identify one another, signal alarm, and attract mates.
Although our olfactory acuity can’t rival that of other animal species, human beings are also guided by smell.
Before the advent of sophisticated laboratory techniques, physicians depended on their noses to help diagnose
illness. A century ago, it was common medical knowledge that certain bacterial infections carry the musty odor
of wine, that typhoid smells like baking bread, and that yellow fever smells like meat. While medical science has
moved away from such subjective diagnostic methods, in everyday life we continue to rely on our sense of
small, knowingly or not, to guide us.
It can be inferred from the passage that the emotional element of human olfaction would be better understood
through investigation into:

Section: Verbal Reasoning 

Options :
Answer: A

Question 2

A researcher in a molecular biology lab planned to carry out an extraction procedure known as an alkaline
plasmid prep, which is designed to purify plasmids, small pieces of the hereditary material DNA, from bacterial
cells. The bacteria are first placed into a test tube containing liquid nutrient medium and allowed to grow until
they reach a high population density. The culture, which consists of solid cells suspended in the medium, is
then centrifuged; a solid pellet is formed. The supernatant is poured out, leaving the pellet behind, and the cells
are resuspended in a mL of lysis buffer solution (50 mM glucose, 25 mM Tris buffer and 10 mM
ethylenediaminetetraacetic acid (EDTA), with 5 mg of the enzyme lysozyme added). They are then incubated
for 30 minutes at 0° C, during which time the bacterial cell walls break down and the cell contents are released
into the solution. After incubation, 1 mL of 0.4 N sodium hydroxide and 1 mL of 2% sodium dodecyl sulfate
(SDS) are added, and the solution is again incubated on ice for 10 minutes. 2 mL of 3 M sodium acetate are
added and the mixture is incubated for 30 minutes at 0° C. The test tube is centrifuged once more and the
supernatant is decanted into a clean tube, leaving behind the protein and most other cell components in the
pellet.
Finally, 10 mL of pure ethanol are added to the supernatant from the previous step to precipitate out the DNA,
and the test tube is incubated at −20° C for 60 minutes, during which the mixture remains liquid. The mixture is
centrifuged a final time and the supernatant removed. The translucent precipitate that results is washed with
70% ethanol (70% ethanol and 30% water by volume), allowed to dry, and resuspended in 1 mL of TE buffer
(10 mM Tris, 1 mM EDTA).
In preparation for this experiment, the researcher prepared stock solutions of the various chemicals that she will
need in the experiment. Stock solutions are highly concentrated solutions of commonly used chemicals in water
from which dilute solutions are prepared for daily use. Table 1 shows the chemicals, their molecular formulas
and weights, and the composition of commonly used stock solutions.
MCAT-part-3-page300-image175
Which of the following conclusions can be reached based on the fact that DNA precipitates in the last step of
the plasmid prep procedure?

Section: Physical Sciences 

Options :
Answer: B

Question 3

The reaction R – Br + Br*– → R – Br* + Br – is always accompanied by inversion. If this reaction is carried out
on an optically pure sample of a chiral compound, which of the following statements will be true? [Note: Br*
represents a radioactive isotope of bromine.]

Section: Biological Sciences 

Options :
Answer: A

Question 4

The anthropomorphic bias of those who would relegate marsupials to an inferior evolutionary status is most
apparent in their recourse to data on brain structure and behavior. Unlike humans and other placentals,
marsupials lack the corpus callosum, which facilitates inter-hemisphere transfer of data acquired through the
senses. Yet it cannot be inferred that marsupials are thus deprived of such function. Didelphis Virginiana, one
of the opossums, makes use of the anterior commissure, an adaptation that is also found in reptiles and
monotremes. Diprodontons, including kangaroos and koalas, supplement the anterior commissure with the
fasciculus aberrans. While the modes of neocortical interconnection may be diverse, the work of Johnson,
Heath and Jones points to the conclusion that, functionally speaking the cortices and neocortices of both
groups of mammals exhibit parallel connections. Parker also notes “a similar range of brain size to body weight
ratios and of neocortical expansion”.
Another stigma borne by marsupials is the consensus that they are less intelligent than placentals. Yet Williams
argues that, all else being equal, natural selection will favor instinctive over learned behavior as being more
biologically efficient and that it is the accidental death of the young that is the prime selective pressure for the
evolution of intelligence. Seen in this light, marsupials have a competitive edge; their gestation period is brief
and the young remain in the pouch for an extended period exposed only to those dangers which also affect the
mother. There they are directly exposed to the mother’s food supply and can observe her behavior at leisure.
Placentals, on the other hand, not only have a longer gestation period but, once their young are born, must
often leave while foraging. Such absences increase the risk of mortality and decrease the opportunity to learn.
Thus, among placentals, selection would favor the apparent intelligence in the young and protective behavior in
the mother.
Marsupials are not known to exhibit maternal protective behavior. In fact, Serventy has reported that frightened
female kangaroos will drop their pouch-young as they flee, drawing a predator’s attention to the less able
offspring while the adult escapes. This behavior, whether purposeful or accidental, instantaneously relieves the
female marsupial of the mechanical difficulties of pregnancy with which her placental counterpart would be
burdened, while marsupials can replace any lost young quickly. Thus, in the absence of any need for close
maternal supervision, sacrificing their offspring in this manner may well have been favored in selection. Pointing
to the absence of the “virtue” of maternal protectiveness in marsupials is an instance of how mistaken are those
theorists who see similarities with humans as marks of evolutionary sophistication.
According to the passage, which of the following favor(s) the development of intelligence as a trait of placental
mammals?
I. The need to leave their young while foraging
II. The comparatively great risk of accidental death of the young
III. The opportunity for the young to observe the mother at leisure

Section: Verbal Reasoning 

Options :
Answer: C

Question 5

The equation of state of an ideal gas is given by the ideal gas law: PV = nRT where P is the pressure, V is the volume, n is the number of moles of gas, R is the ideal gas constant, and T is the temperature of the gas. The gas particles in a container are constantly moving at various speeds. These speeds are characterized by the Maxwell shown in the figure below.

MCAT-part-1-page303-image25
If two particles collide, their velocities change. However, if the gas is in thermal equilibrium, the velocity
distribution of the gas as a whole will remain unchanged by the collision.
The average kinetic energy (E) of a gas particle is given by:
MCAT-part-1-page303-image24
Equation 1
where m is the mass of one particle and u is the root mean square speed (rms speed) of the gas particles:
MCAT-part-1-page303-image23
where N is the number of gas particles; this is different from the average speed. For an ideal gas, the kinetic
energy of all the particles is:
MCAT-part-1-page303-image22
Equation 2
where n is the number of moles of gas. Combining these equations gives:
MCAT-part-1-page303-image21
Equation 3 where M is the molar mass of the gas particles. The average distance a particle travels between collisions is known as the mean free path l. Intuitively, the mean free path (mfp) could be expected to be larger for gases at low pressure, since there is a lot of space between particles. Similarly, the mfp should be larger when the gas particles are small. The following expression for the mfp shows this to be correct.
MCAT-part-1-page303-image30
Equation 4
In this equation, s is the atomic diameter (typically on the order of 10-8), k is the Boltzmann constant, and P is
the pressure.
In addition to colliding with one another, gas particles also collide with the walls of their container. If the
container wall has a pinhole that is small compared to the mfp of the gas, and a pressure differential exists
across the wall, the particles will effuse (or escape) through this pinhole without disturbing the Maxwellian
distribution of the particles. The rate of effusion can be described by:
MCAT-part-1-page303-image29
Equation 5
Where neff is the number of moles of effusing particles, A is the area of the pinhole, P and P1 are the pressures
on the inside and outside of the container wall respectively, and P > P1.
Which of the following will have the smallest root mean square speed at 298K?

Section: Physical Sciences 

Options :
Answer: A

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